THE CLATHRIN ASSEMBLY PROTEIN PICALM IS REQUIRED FOR ERYTHROID MATURATION AND TRANSFERRIN INTERNALIZATION IN MICE.

The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice.

Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid leukemia protein (CALM), was originally isolated as click here part of the fusion gene CALM/AF10, which results from the chromosomal translocation t(10;11)(p13;q14).CALM is sufficient to drive clathrin assembly in vitro on lipid monolay

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An unusual congenital hepatic cyst in an adolescent and review of differential diagnoses of complex liver cysts

The diagnosis of a simple hepatic cyst is not difficult, but diagnostic confusion occurs when atypical features such as intracystic debris or extremely large size are present.In children, click here simple liver cysts are described as small, asymptomatic, and rarely hemorrhagic.We report an adolescent male presenting with an click here unusually la

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Adaptive eQTLs reveal the evolutionary impacts of pleiotropy and tissue-specificity while contributing to health and disease

Large numbers of expression quantitative trait loci (eQTLs) have recently been identified in humans, and many of these regulatory variants have large allele frequency differences between populations.Here, we conducted genome-wide scans of selection to identify adaptive eQTLs (i.e., eQTLs stuart products emcelle tocopherol with large population bran

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